The sweet spot for most post-thrombolytic patients (once your doctors give the OK) is small, consistent, and boring: one to two moderate cups per day, earlier rather than later, paired with aggressive risk-factor management (BP, lipids, smoking cessation, weight, exercise). If you’ve been told “no caffeine” because of arrhythmias, uncontrolled hypertension, or severe insomnia, coffee needs to stay off the table until that advice changes.