For coffee lovers, the key point is that GLP-1 RAs don’t directly interact with caffeine, and they don’t rely on the same liver enzymes. Your main concern is how coffee fits into your overall carb intake, weight-loss goals, and GI comfort. A very milky or sugary latte can blunt some of the metabolic benefits you’re getting from your GLP-1 therapy, while a plain or lightly sweetened coffee often fits nicely into a diabetes-friendly plan.